Sirtuin-dependent clock control
نویسندگان
چکیده
منابع مشابه
Cell size control is sirtuin(ly) exciting
In the classic essay ‘On longevity and shortness of life’Aristotle speculated on the causes of the length or brevity of lifespan. More than 23 centuries ago, he postulated that three factors have major effects on longevity: metabolic rate, reproductive rate, and size. Remarkably, these observations still hold true. However, the molecular and genetic mechanisms that are responsible for these fun...
متن کاملCysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation
Sirtuin-1 (SIRT1) regulates hepatic metabolism but its contribution to NF-κB-dependent inflammation has been overlooked. Cysteine cathepsins (Cathepsin B or S, CTSB/S) execute specific functions in physiological processes, such as protein degradation, having SIRT1 as a substrate. We investigated the roles of CTSB/S and SIRT1 in the regulation of hepatic inflammation using primary parenchymal an...
متن کاملSirtuin-1 is a nutrient-dependent modulator of inflammation
Inflammation accompanies obesity and its comorbidities-type 2 diabetes, non-alcoholic fatty liver disease and atherosclerosis, among others-and may contribute to their pathogenesis. Yet the cellular machinery that links nutrient sensing to inflammation remains incompletely characterized. The protein deacetylase sirtuin-1 (SirT1) is activated by energy depletion and plays a critical role in the ...
متن کاملClock Control OUTPUT SHIFT DIRECTION
This paper shows how a well-balanced trade-oo between a generic workstation and dumb but fast reconngurable hardware can lead to a more eecient implementation of a cryptanalysis than a full hardware or a full software implementation. A realistic cryptanalysis of the A5/1 GSM stream cipher is presented as an illustration of such trade-oo. We mention that our cryptanalysis requires only a minimal...
متن کاملRapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1
Maintenance of Foxp3 protein expression in regulatory T cells (Treg) is crucial for a balanced immune response. We have previously demonstrated that Foxp3 protein stability can be regulated through acetylation, however the specific mechanisms underlying this observation remain unclear. Here we demonstrate that SIRT1 a member of the lysine deacetylase Sirtuin (SIRT) family, but not the related S...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Clinical Nutrition and Metabolic Care
سال: 2015
ISSN: 1363-1950
DOI: 10.1097/mco.0000000000000219